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1

Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells

Seifert, Tina, Malo, Marcus, Kokkola, Tarja, Engen, Karin, Fridén-Saxin, Maria, Wallén, Erik A. A., Lahtela-Kakkonen, Maija, Jarho, Elina M., Luthman, Kristina

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2014

2

N-Acylethanolamines Bind to SIRT6

Rahnasto-Rilla, Minna, Kokkola, Tarja, Jarho, Elina, Lahtela-Kakkonen, Maija, Moaddel, Ruin

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 625 KB

english, 2016

3

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

Tarja Kokkola, Juha R Savinainen, Kati S Mönkkönen, Montse Durán Retamal, Jarmo T Laitinen

Journal:

BMC Cell Biology

Année:

2005

Langue:

english

Fichier:

PDF, 4.16 MB

english, 2005

4

Cholinergic signaling in the rat pineal gland

Jarmo T. Laitinen, Kirsti S. M. Laitinen, Tarja Kokkola

Journal:

Cellular and Molecular Neurobiology

Année:

1995

Langue:

english

Fichier:

PDF, 1.23 MB

english, 1995

5

Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity

Mustafa Atalay, Ayca Bilginoglu, Tarja Kokkola, Niku Oksala, Belma Turan

Journal:

Molecular and Cellular Biochemistry

Année:

2011

Langue:

english

Fichier:

PDF, 308 KB

english, 2011

6

Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat

Raimo Pohjanvirta, Jarmo T. Laitinen, Olli Vakkuri, Jere Lindén, Tarja Kokkola, Mikko Unkila, Jouko Tuomisto

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.21 MB

english, 1996

7

The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor

Tarja Kokkola, Outi M. H. Salo, Antti Poso, Jarmo T. Laitinen

Journal:

Journal of Pineal Research

Année:

2005

Langue:

english

Fichier:

PDF, 417 KB

english, 2005

8

Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation

Tarja Kokkola, Maija Vaittinen, Jarmo T. Laitinen

Journal:

Journal of Pineal Research

Année:

2007

Langue:

english

Fichier:

PDF, 609 KB

english, 2007

9

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor

Juha R Savinainen, Tarja Kokkola, Outi M H Salo, Antti Poso, Tomi Järvinen, Jarmo T Laitinen

Journal:

British Journal of Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 307 KB

english, 2005

10

Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase

Tarja Kokkola, Claudia Kruse, Eva-Maria Roy-Pogodzik, Jenna Pekkinen, Carola Bauch, Hans-Hinrich Hönck, Hanjo Hennemann, Hans-Jürgen Kreienkamp

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 971 KB

english, 2011

11

Important amino acids for the function of the human MT1 melatonin receptor

Tarja Kokkola, Steven M. Foord, Marie-Ange Watson, Olli Vakkuri, Jarmo T. Laitinen

Journal:

Biochemical Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 317 KB

english, 2003

12

Mutagenesis of Human Mel1aMelatonin Receptor Expressed in Yeast Reveals Domains Important for Receptor Function

Tarja Kokkola, Marie-Ange Watson, Julia White, Simon Dowell, Steven M. Foord, Jarmo T. Laitinen

Journal:

Biochemical and Biophysical Research Communications

Année:

1998

Langue:

english

Fichier:

PDF, 124 KB

english, 1998

13

A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor

Cecil Navajas, Tarja Kokkola, Antti Poso, Nina Honka, Jukka Gynther, Jarmo T. Laitinen

Journal:

European Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 952 KB

english, 1996

14

Melatonin receptor genes

Kokkola, Tarja, Laitinen, Jarmo T

Journal:

Annals of Medicine

Année:

1998

Langue:

english

Fichier:

PDF, 747 KB

english, 1998

15

Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

Mellini, Paolo, Kokkola, Tarja, Suuronen, Tiina, Salo, Heikki S., Tolvanen, Laura, Mai, Antonello, Lahtela-Kakkonen, Maija, Jarho, Elina M.

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 2.01 MB

english, 2013

16

AROS has a context-dependent effect on SIRT1

Kokkola, Tarja, Suuronen, Tiina, Molnár, Ferdinand, Määttä, Juha, Salminen, Antero, Jarho, Elina M., Lahtela-Kakkonen, Maija

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 719 KB

english, 2014

17

Studying SIRT6 regulation using H3K56 based substrate and small molecules

Kokkonen, Piia, Rahnasto-Rilla, Minna, Mellini, Paolo, Jarho, Elina, Lahtela-Kakkonen, Maija, Kokkola, Tarja

Journal:

European Journal of Pharmaceutical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 583 KB

english, 2014

18

Virtual screening approach of sirtuin inhibitors results in two new scaffolds

Kokkonen, Piia, Kokkola, Tarja, Suuronen, Tiina, Poso, Antti, Jarho, Elina, Lahtela-Kakkonen, Maija

Journal:

European Journal of Pharmaceutical Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2015

19

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

Oksala, Niku K.J., Ekmekçi, F. Güler, Özsoy, Ergi, Kirankaya, Şerife, Kokkola, Tarja, Emecen, Güzin, Lappalainen, Jani, Kaarniranta, Kai, Atalay, Mustafa

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 456 KB

english, 2014

20

Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment

Pesonen, Maija, Storvik, Markus, Kokkola, Tarja, Rysä, Jaana, Vähäkangas, Kirsi, Pasanen, Markku

Journal:

Chemical Research in Toxicology

Année:

2015

Langue:

english

Fichier:

PDF, 5.50 MB

english, 2015

21

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

Yrjölä, Sari, Parkkari, Teija, Navia-Paldanius, Dina, Laitinen, Tuomo, Kaczor, Agnieszka A., Kokkola, Tarja, Adusei-Mensah, Frank, Savinainen, Juha R., Laitinen, Jarmo T., Poso, Antti, Alexander, Amy,

Journal:

European Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 2.54 MB

english, 2016

22

BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

Kokkola, Tarja, Suuronen, Tiina, Pesonen, Maija, Filippakopoulos, Panagis, Salminen, Antero, Jarho, Elina M., Lahtela-Kakkonen, Maija

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 867 KB

english, 2015

23

Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation

Yaluri, Nagendra, Modi, Shalem, Kokkola, Tarja

Journal:

Biochemical and Biophysical Research Communications

Année:

2016

Langue:

english

Fichier:

PDF, 2.30 MB

english, 2016

24

Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells

Modi, Shalem, Yaluri, Nagendra, Kokkola, Tarja, Laakso, Markku

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 2.67 MB

english, 2017

25

Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Kärkkäinen, Jussi, Gynther, Mikko, Kokkola, Tarja, Petsalo, Aleksanteri, Auriola, Seppo, Lahtela-Kakkonen, Maija, Laine, Krista, Rautio, Jarkko, Huttunen, Kristiina M.

Journal:

International Journal of Pharmaceutics

Année:

2018

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2018

26

Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes

Modi, Shalem, Yaluri, Nagendra, Kokkola, Tarja

Journal:

Biochemical and Biophysical Research Communications

Année:

2018

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2018

27

Strigolactone GR24 upregulates Nrf2 target genes and may protect against oxidative stress in skeletal muscle

Modi, Shalem Raju, Kokkola, Tarja

Journal:

Année:

2018

Fichier:

PDF, 726 KB

2018

28

Strigolactone GR24 upregulates Nrf2 target genes and may protect against oxidative stress in skeletal muscle

Modi, Shalem Raju, Kokkola, Tarja

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 726 KB

english, 2018

29

Impact of structurally diverse BET inhibitors on SIRT1

Tenhunen, Jonna, Kokkola, Tarja, Huovinen, Marjo, Rahnasto-Rilla, Minna, Lahtela-Kakkonen, Maija

Journal:

Année:

2020

Fichier:

PDF, 769 KB

2020